GPEx® technology expresses any type of IgG mAb: full-length mAbs, Fab fragments, chimeric antibodies, antibody fusion proteins and single-chain antibodies. Variable regions can be inserted into our retrovectors for cell line development and protein production.
Catalent Pharma Solutions maintains backbone vectors containing the gamma constant region for human IgGs 1, 2, 3 and 4 and light-chain kappa and lambda regions. DNA sequences encoding IgG variable regions can be fused to any constant region in the GPEx retrovector system. Using this system, we can produce any desired IgG molecule.
Variant analysis: GPEx technology is ideal for variant analysis. We can deliver milligram amounts of several protein variants from a stable pool quickly. A selected clone can then be used for a fast path to clinical manufacturing.
For capabilities that meet your needs, and outcomes that exceed your expectations, partner with Catalent today. For more information contact us at gpexinfo@catalent.com or call a member of our sales staff at +1 (608) 821.6249.