EnCirc® pellets for higher drug loading:

EnCirc® pellets can be used for immediate and controlled-release capsules or tablets.

Attributes

High-potency pellets

Predictable mean-size and narrow-size distribution

High sphericity

Low friability

Benefits

Typical drug loading exceeds 80%

Reproducible drug-release profiles

Uniformity of dose

Reproducible drug-release profiles

Uniform coatings due to fewer surface imperfections than nonpareils

Durable product that withstands rigorous coating processes

EnVel® system for taste masking:

EnVel® is a system of proprietary taste-masking technologies for chewable tablets. The active ingredient is enveloped as a matrix using pharmaceutically acceptable excipients or the active is isolated as discrete particles using a hydrocolloid polymer.

EnVel® technologies can greatly improve patient acceptance of Rx or OTC chewable tablets. The drug-dissolution profile remains unchanged.

Attributes

Effective taste masking

Unique drug-polymer matrix

Higher drug loading

Drug-particle isolation barriers

Benefits

Greatly improved palatability of a wide variety of active ingredients

Taste-masking properties are not affected by chewing or compression

Smaller dosage forms

Improved patient compliance

Drug particles are isolated from fluids during chewing

EnSolv® for improved dissolution:

EnSolv® technologies can provide a formulation solution for new chemical entities as well as extend life cycles of many marketed products.

Two EnSolv® technologies are available to modify certain drug crystals by way of:

• solid dispersion using a hot-melt process, or
• aqueous deposition

EnSolv® for solid dispersion:

A hot-melt technology that transforms the drug crystals into a higher-energy amorphous state, thus providing improved dissolution of an insoluble active ingredient.

Attributes

Improved dissolution

Unlocks the potential of poorly soluble drugs by allowing a stable supersaturated solution to form

Benefits

Fine-particle solid ?dispersion

Stable, fine powder for compression or encapsulation

EnSolv® for aqueous deposition:

A patented co-processing technology that generates a suspension in the stomach, and is for use in immediate-release capsules or tablets.

Attributes

Faster dissolution

Performs similar to a suspension

Improved content uniformity

Improved stability by coating

Improved compressibility

Higher drug loading

Improved material flow

Benefits

Unlocks the potential of poorly soluble drugs

Rapid and complete exposure of high drug-surface area

Consistently meets specifications

Withstands further processing and severe storage conditions

Improves processing for difficult-to-formulate actives

Increases dosing alternatives

Improves processing for difficult-to-formulate actives

Particle coatings for controlled release:

Custom modified-release formulations are specifically designed to meet the desired drug release profile.

Benefits:

Incompatibility barrier

Taste masking

Delayed or controlled release

Enteric coating

Post gastric release