Zydis is a unique, freeze-dried oral solid dosage form that can be swallowed without water, because it dissolves instantly on the tongue in less than 3 seconds. This unsurpassed dissolution speed translates to dosing convenience and ease of administration, and that makes Zydis an ideal application for a wide range of patients and indications.
Zydis is the fastest dissolving oral tablet in the world, but speed is just one area where this technology is superior to other fast-dissolve dosage forms.
| Feature | Zydis | Compressed |
|---|---|---|
| Speed of dispersion | < 3 secs | > 20 secs |
| Mouthfeel | Smooth | Gritty |
| Dose handling | < 500 mg | < 500 mg |
| Taste masking | Yes | Yes |
Manufacturing and packaging
Zydis technology utilizes a unique freeze-drying process to manufacture finished dosage units, which vary from conventional oral dosage forms.
- Stage 1 - The production sequence begins with the bulk preparation of an aqueous drug solution or suspension and subsequent precise dosing into pre-formed blisters. It is the blister that actually forms the tablet shape and is, therefore, an integral component of the total product package.
- Stage 2 - The second phase of manufacturing entails passing the filled blisters through a specially designed cryogenic freezing process to control the ultimate size of the ice crystals. This aids in ensuring that the tablet possesses a porous matrix to facilitate the rapid disintegration function. These frozen units are then transferred to large-scale freeze dryers for the sublimation process, whereby the majority of the remaining moisture is removed from the tablets.
- Stage 3 - The final phase of production involves sealing the open blisters via a heat-seal process to ensure stability and to protect the product from varying environmental conditions.
Product benefits:
The benefits of using Zydis technology have been proven the world over. Zydis-based products have regulatory approval in more than 50 countries and have played a leading role in multiple new product launches. In addition to improving the quality and performance of each product, our technology - specific development group and their experience can streamline the overall development process, helping your product reach the market more quickly.
Enhanced performance:
Zydis delivery technology can help enhance your product’s performance in a multitude of ways. The rapid dispersion and coating with Zydis in the buccal cavity creates products that can:
- provide easier administration; no water required
- improve patient compliance
- decrease onset time
- modify absorption
- increase bioavailability
- augment therapeutic efficacy
Increased protection:
Because Zydis requires significant proprietary know-how in formulation development and manufacturing, and an equally significant capital investment, your product has added protection from generic competition and counterfeiting.
- over 20 years of proven success
- more than 300 patents worldwide
Effective differentiation:
Zydis offers effective differentiation from the competition because it is highly customizable, including:
- custom colors and shapes
- tablet debossing with corporate logos and product codes
- unique packaging systems, including child-resistant options
Expanded usage:
The excellent pharmacokinetics and patient-preferred features of Zydis can streamline the development process while expanding the market for your product across a broad range of indications and patient types, including:
- young, elderly and active patients
- Rx and OTC applications
- challenging therapeutic areas where compliance is critical
- veterinary medicine
For capabilities that meet your needs, and outcomes that exceed your expectations, partner with Catalent today. For more information fill out our contact us form or call a member of our sales staff toll-free at 866.720.3148.