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DEVELOPMENT: BIOPHARMACEUTICAL LAB SERVICES
Catalent offers the ability to perform a wide range of biophysical analysis with many years of analytical service experiences, technical expertise, and advanced instrumentations. This includes the characterization of novel proteins, peptides and oligonucleotides, analysis of biosimilars, characterization of reference standards, and release testing of these products. The biophysical characterization group at Catalent works closely with the client to help you understand your molecule from discovery to commercial products.
- Peptide mapping by UV or HPLC-MS and MSMS
- Protein sequence confirmation
- Disulfide Bond Analysis by HPLC-MS
- Free Cysteine Analysis
- Intact Molecular Weight Analysis (Proteins, Peptides, Oligonucleotides)
- Impurity identification by HPLC-MS and MSMS
- Glycoprofiling by HPLC-MS and MSMS for site occupancy and heterogeneity
- Post-translational modification analysis (oxidation, deamidation, phosphorylation)
- Quantitative Monosaccharide Analysis (Fluorescent detection or HPAE-PAD)
- Quantitative Sialic acid Analysis (Fluorescent detection or HPAE-PAD)
- Oligosaccharide profiling (Fluorescent detection or HPAE-PAD)
- HPLC chromatography (reverse phase, ion exchange, size exclusion)
- Electrophoresis (SDS-PAGE, IEF and 2D-gels)
- Capillary Electrophoresis (CZE, cIEF and CE-SDS
- Mass spectrometric analysis, Q-Tof LC/MS/MS, Ion Trap, MSD
- N-terminal sequencing
- Amino Acid Analysis (Peptide Content and Molar Ratios)
- Extinction Coefficient Determination
- Free Sulfhydral Analysis (Colorimetric assay)
- Blotting analysis
Facilities
