Catalent Micron Technologies



Multi-Processing Systems For Size Milling And Classification

When you’re dealing with narrow particle size requirements, pharmaceutical companies need to partner with a supplier who can offer the right equipment, as well as expertise and experience. At Catalent Micron Technologies, we’ve worked to develop micronization capabilities for the most challenging particle size requirements and pharmaceutical compounds, such as inhalation grade powders and active ingredients used in softgel capsule suspensions.

Micronize and Classify Pharmaceutical Compounds

Located in our Dartford, U.K., facility, our multi-processing classifier mill can provide unique solutions because of its ability to both micronize and classify a powder. It provides a much more narrow particle size distribution than traditional micronizing or milling techniques. This multi-processing system is often a perfect fit for inhalation grade powders or for any formulation where very fine or large particles must be minimized. This mill can be used for potent compounds and can be combined with Catalent’s customized containment system.

How Particle Size Classifiers Work

Traditional spiral jet micronizers rely on centrifugal forces to control the particle size. Our pharmaceutical multi-processor uses an integrated ultrafine classifier wheel, which ensures very accurate control when the particles exit the mill.

  • Typical application area All pharmaceutical materials requiring narrow particle size distribution, including inhalation products, suspensions and modified release applications
  • Typical size range d97 of 4μm, d50 approximately 2μm
  • Batch size From 400g and up

Functions

  • Micronize - d50 of 1μm to 30μm
  • Mill - d50 of 10μm to 250μm
  • Classify - Split a powder into two fractions

All the above functions will allow a narrow distribution of particle size, as an example, a d50 of 5μm may have a d10 of 1μm and a d90 of 7μm*

*Example only, distribution may vary with material properties

For more information on particle size requirements in pharmaceutical manufacturing, explore our ‘Thinking’ resource library today.