Tablets

Customizing competitive tablets to your most stringent formulation requirements

As the premier innovator of coated multi-particulate dosage forms, we also offer expert development and manufacturing services for oral solid tablets (as well as powders, pellets, beads, and granules). Backed by a wide range of dose release options - from immediate to modified (including our proprietary Zydis^® fast dissolve) - our highly trained scientists can help you develop formulations, then customize hardshell tablets to match specific requirements, thus enhancing your therapeutic outcome. Our experience is vast; we produce over 700,000,000 tablets per year - working with potent APIs, non-chlorinated organic solvents, and all schedules of DEA-controlled substances. As well, our manufacturing expertise - in particular, around fluid bed technology - can help further distinguish your product in a highly competitive market.

Catalent Benefits 

• Integrated services from development to market
• Preformulation and formulation expertise solving numerous challenges
• Innovative proprietary release technologies that optimize delivery
• Network of FDA-compliant facilities
• Project management teams with on-point contact
• Reliable, customized clinical supply
• Track record of regulatory success in NDAs and ANDAs
• Extensive expertise, experience, and capacity for full-scale production
• Traditional hard tablets 
• Bi-layer tablets
• Combines two different APIs into a single tablet, or an immediate-release component with a controlled-release component

Valuable Product Differentiation 

• Dose release options
  • Immediate Release
  • Modified Release
    • Controlled Release 
  • Delayed Release/Enteric Release
  • Repeat Action or Pulse Release
• Proprietary technologies
  • Zydis^® fast dissolve 
    • No. 1 selling technology that enhances pre-gastric absorption

How It Works

• Essential tablet characteristics defined and determined during formulation development 
• API formulated with excipients to produce powder or granulation for the tablet presses
• Material compressed into tablets on a tablet press
• Tooling of presses varied to create a variety of tablet shapes, sizes, and embossed designs

Catalent Services 

Our expert team of scientists can advise you which of our numerous methods is most suited to your tablet production:

• Matrix 
• Osmotic pump 
• Functionally coating
• Pan layering/coating of tablets
• Extrusion/spheronization/coating
• High drug load
• Fluidized bed layering/coating

Catalent Capabilities

• Tablet presses
  • Manesty Express 700 (61 station “B” and 49 station “D” double-sided and bi-layer)
  • Manesty Express “B” and “D” tooled
  • Korsch PH300 (29 station “D” tooled, single sided)
  • Bosch, Index & H&K 1500 capsule fillers all with IMA Precisa 120 weight sorters
• Tablet coaters
  • Fully perforated pan-coaters
  • Solvent or aqueous
  • Available sizes
    • 5” to 30” (Somerset)
    • 24” to 60” (Winchester)
• Controlled substance processing
  • Capability of ordering, storing, testing, and processing of DEA Schedules II – V
  • Significant experience processing controlled release morphine analogs and amphetamines
  • Tablet and capsule dosage forms
  • 24/7 security
  • Video surveillance of processing rooms
  • 110 pallet space narcotics vault

Facilities

• Somerset, NJ, U.S.A.
  • Commercial and development
  • Isolation technologies
    • Milling
    • Roller compacting
    • Granulating
    • Drying
    • API mixing
    • Sieving
    • Tableting
    • Capsule filling
    • Blending
    • Tablet & bead coating
• Winchester, KY, U.S.A.
  • Category I – II I and solvent-based processing
  • Extrusion and spheronization
  • Commercial high-shear granulation
  • Blending
  • Tablet compression
  • Hardshell capsule filling
  • Pan-coating
• Schorndorf, Germany
  • Category I – IV and solvent- based processing
  • Commercial high-shear granulation
  • Blending
  • Dry granulation
  • Extrusion and spheronization
  • Tablet compression
  • Hardshell capsule filling
  • Pan coating