OptiForm Pro

EXPLORE THE RANGE OF DELIVERY OPTIONS TO YOUR MOLECULE
This tool has been designed to help formulation scientists explore available options based on their small molecule target indication and specific product requirements.

Take 8 minutes to enter what you know about your molecule's key dimensions to see its Developability Classification and potential formulation options.

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TELL US WHAT YOU KNOW ABOUT YOUR MOLECULE
Selecting the right formulation technology to quickly and effectively solve bioavailability, stability and scability challenges is a vital task early in the oral drug development process.
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OUR PATENT-PENDING OPTIMUM® PRO TOOL PROCESSES THAT INFORMATION ACROSS 24 DIMENSIONS

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YOU'LL RECEIVE SOLUTIONS ACROSS A NUMBER OF TECHNOLOGIES
Results are based on our experience and learnings from thousands of molecules Catalent experts have worked on.
OptiForm Pro
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DEVELOPABILITY CLASSIFICATIONalt
The DCS model is an application of biopharmaceutics concepts specifically designed for formulation development. knowledge of formulation strategies for similar compounds in the same DCS-space to your candidate allows for insight into the optimum formulation approach. Please input your Predicted Permeability in Humans, your Solubility in FAaSSIF or Water & the Target Dose. If you have not yet calculated these values, you may be able to by using many online prediction tools.
The DCS model is an application of biopharmaceutics concepts specifically designed for formulation development. knowledge of formulation strategies for similar compounds in the same DCS-space to your candidate allows for insight into the optimum formulation approach. Please input your Predicted Permeability in Humans, your Solubility in FAaSSIF or Water & the Target Dose. If you have not yet calculated these values, you may be able to by using many online prediction tools.
*All fields required.

PEFF VALUE (PREDICTED PERMEABILITY IN HUMANS)

(cm/s 10^-4)

Invalid peff value (0.1 - 30)

SOLUBILITY IN FASSIF (OR LESS OPTIMALLY, WATER)

(mg/mL)

Invalid S (0 – 1,000,000)

UPPER DOSE IN DOSE ESCALATION (IN MG)

(mg)

Invalid target dose (0 - 100,000)

OptiForm Pro
10%
COMPLETE

PRODUCT REQUIREMENTSalt
Determining your target product profile will assist us in developing a tailored solution for your molecule’s challenges. Select the characteristics you are targeting for your product as they each relate to its therapeutic window, proposed patient population and type.
Determining your target product profile will assist us in developing a tailored solution for your molecule’s challenges. Select the characteristics you are targeting for your product as they each relate to its therapeutic window, proposed patient population and type.
*All fields required.

CHEWABLE
  • Yes
  • No
  • Don't know

VAGINAL
  • Yes
  • No
  • Don't know

FAST ONSET OF ACTION (Faster than 45min dissolution time)
  • Yes
  • No
  • Don't know

CONTROLLED RELEASE (or lower CMAX)
  • Yes
  • No
  • Don't know

DELAYED RELEASE (>60 minute dissolution time)
  • Yes
  • No
  • Don't know

COMBINATION PRODUCT
  • Yes
  • No
  • Don't know

PEDIATRIC/GERIATRIC PATIENT POPULATION
  • Yes
  • No
  • Don't know

OptiForm Pro
35%
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ABOUT YOUR MOLECULEalt
90% of NCEs in today’s development pipeline suffer from poor aqueous solubility, poor permeability, or both. Select the solubility and permeability properties for your molecule.
90% of NCEs in today’s development pipeline suffer from poor aqueous solubility, poor permeability, or both. Select the solubility and permeability properties for your molecule.
*All fields required.

PARTITION COEFFICIENT
  • LogP less than 1
  • LogP Between 1-4
  • LogP Greater than 4
  • Don't know

IS YOUR COMPOUND A MACROMOLECULE?
  • Yes
  • No
  • Don't know

OptiForm Pro
50%
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PHYSIOCHEMICAL PROPERTIESalt
Physiochemical properties of your molecule have an effect on the formulation challenges associated with delivering the molecule in the optimal dosage form to the site of action. Select the physical characteristics of your molecule.
Physiochemical properties of your molecule have an effect on the formulation challenges associated with delivering the molecule in the optimal dosage form to the site of action. Select the physical characteristics of your molecule.
*All fields required.

MELTING POINT
The temperature at which it changes state from solid to liquid at atmospheric pressure.
  • Greater than 70°C
  • Less than 70°C
  • Don't know

PHYSICAL STATE AT ROOM TEMP
Distinct form of matter that your API takes on when at room temperature.
  • Amorphous
  • Crystalline
  • Liquid Phase
  • Don't know

MOLECULAR STABILITY ISSUES
Certain physical and chemical conditions can lead to the formation of impurities and degradation products. Select which of the following conditions your molecule and/or formulation is sensitive to.
  • Hydrolysis
  • Heat (50°C - 80°C)
  • Oxydation
  • Acid
  • Enzymatic Degradation of the Intestines
  • None of the above
  • Don't know

DOES YOUR COMPOUND HAVE OR IS LIKELY TO DEGRADE TO ALDEHYDE FUNCTIONAL GROUPS?
Aldehydes are highly reactive and participate in many reactions.
  • Yes
  • No
  • Don't know

OptiForm Pro
65%
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POTENT HANDLING AND DOSAGEalt
Target dosage and processing characteristics of your molecule have an affect on the manufacturing challenges and solutions available in order to deliver the drug in the optimal dosage form. Select the corresponding characteristics of your molecule.
Target dosage and processing characteristics of your molecule have an affect on the manufacturing challenges and solutions available in order to deliver the drug in the optimal dosage form. Select the corresponding characteristics of your molecule.
*All fields required.

IS YOUR COMPOUND A HORMONE OR CYTOTOXIC?
Historically, regulatory authorities have assigned certain APIs to various “categories of concern”, based on their toxicological properties, in the interest of protecting patients from exposure to potentially hazardous contaminants.
  • Yes
  • No
  • Don't know

POTENCY CLASSIFICATION (Occupational exposure limit (OEL)ug/m3)
Molecules are becoming increasingly more and more selective in their interaction with biological targets, with pharmacological activity often being achieved with minute amounts of drug. The manufacture of highly potent drug substances and their drug products requires particular care and attention in ensuring the safety for those involved in the handling of the materials. Select if your molecule is pharmacologically active in these dose ranges.
  • Category 1
  • Category 2
  • Category 3
  • Category 4
  • Dont't know

AMOUNT PER UNIT (Select two: Highest and Lowest)
Please select the therapeutic dose range you are targeting with this molecule.
  • < 1mg
  • 1 - 4 mg
  • 5 - 200mg
  • 200 - 500mg
  • > 500mg
  • Don't know

POOR FLOW (Carr's index>18)
Physical characteristics of particles, like size, shape, angularity, surface texture and porosity will all affect flow characteristics. Select if your molecule has poor particle flow properties.
  • Yes
  • No
  • Don't know

OptiForm Pro
100%
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SUBMIT INFORMATION FOR ANALYSIS
Register now and we will provide you with your results on potential finished dose solutions specific to your molecule
*All fields required.

NAME*
Please enter your first namePlease enter your last name
COMPANY/ORGANIZATION*
Please enter your company/organization name
TELEPHONE NUMBER
Please enter your telephone number
NAME YOUR MOLECULE
Please enter your molecule