Formulating Oils In The Zydis® Freeze Dried Orally Disintegrating Tablet

Summary: The Zydis® freeze-dried dosage form is typically produced from an aqueous solution or suspension of the active pharmaceutical ingredient (API) along with any other required excipients such as colors, flavors or sweeteners. This is dosed into blister pockets and frozen by passing through a liquid nitrogen freeze tunnel,before being freeze-dried to produce the orally disintegrating tablet (ODT).There are many instances where the API may be in the form of an oil or it maybe desirable to solubilise the API in an oil in order to improve its bioavailability.This study demonstrated that relatively high concentrations of various oils can be successfully incorporated into the Zydis® freeze-dried orally disintegrating tablet. The tablets produced had an elegant appearance and excellent dispersion times.

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