Pharamcokinetics of Fenofibrate Nanoparticles Stabilized

Pharamcokinetics of Fenofibrate Nanoparticles Stabilized and Delivered Using the Zydis® Technology

Authors: Deepak Bahl, Senior Scientist, Catalent & Kieran Crowley, Formulations Manager, Catalent

To evaluate the pharmacokinetic (PK) behavior of nanosized fenofibrate administered orally in a stabilized freeze-dried dosage form. The pharmacokinetics of three dosage forms were investigated: aqueous nanosuspension (F1), nanosized fenofibrate in freeze-dried tablet (F2), micron-sized fenofibrate in freeze-dried tablet (F3).