Hot Melt Extrusion And OptiDose™ Technology

There has been much interest during the past decade in hot melt extrusion for the development of drug products to overcome API solubility challenges. The technology is especially promising in the development and stabilization of high-energy (e.g. amorphous) forms of poorly water-soluble APIs. This occurs by solid dispersion in polymeric carriers that enhance their dissolution rates and bioavailability, ultimately leading to better treatments.

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