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12th Annual World ADC London

Schedule a Meeting with Catalent at 12th Annual World ADC London

Date: March 29-April 1, 2022
Location: London, UK





Ayodele Ogunkoya
Sr. Research Scientist, Chemical Biology, Catalent


Session Title:  Advances in SMARTag® technology for the preparation of site-specifically modified antibody-drug conjugates with stable hydrophilic linkers and higher DARs
Session Date: Tuesday, March 29, 2022
Session Time: 11:15AM – 11:45AM BST

    • SMARTag is a clinical-stage technology featuring site-specific conjugation with multiple linker, warhead, and conjugation site options to consistently and reproducibly prepare uniform ADCs.
    • Our newest linker designs—including our novel tandem-cleavage element, which pairs excellent circulating stability with ready cleavage upon internalization—are featured on high DAR ADCs with a diverse set of payloads. These linkers are used in conjunction with optimized conjugation sites to deliver ADCs with exceptional PK and xenograft efficacy, which are leading to promising clinical candidates.
    • We emphasize conjugate stability and hydrophilicity to produce ADCs with enhanced biophysical properties through the versatility of our stable C-C bond forming HIPS molecule as well as proprietary stable and hydrophilic linkers.