12th Annual World ADC London
Date: March 29-April 1, 2022
Location: London, UK
Sr. Research Scientist, Chemical Biology, Catalent
Session Title: Advances in SMARTag® technology for the preparation of site-specifically modified antibody-drug conjugates with stable hydrophilic linkers and higher DARs
Session Date: Tuesday, March 29, 2022
Session Time: 11:15AM – 11:45AM BST
- SMARTag is a clinical-stage technology featuring site-specific conjugation with multiple linker, warhead, and conjugation site options to consistently and reproducibly prepare uniform ADCs.
- Our newest linker designs—including our novel tandem-cleavage element, which pairs excellent circulating stability with ready cleavage upon internalization—are featured on high DAR ADCs with a diverse set of payloads. These linkers are used in conjunction with optimized conjugation sites to deliver ADCs with exceptional PK and xenograft efficacy, which are leading to promising clinical candidates.
- We emphasize conjugate stability and hydrophilicity to produce ADCs with enhanced biophysical properties through the versatility of our stable C-C bond forming HIPS molecule as well as proprietary stable and hydrophilic linkers.