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CASSS WCBP

Schedule a Meeting with Catalent at CASSS WCBP

Location: Washington, D.C.
Date: January 28-30, 2020
Stand: 18

Catalent Technical Seminar

Presenter: Chris Hepler, Manager, Lab Operations, Biologics
Date: Tuesday, Jan 28
Time: 12:50 – 1:50PM
Location: District Ballroom on Tuesday
Title: Conversion of a potency assay from cell-based binding to AlphaLISA
Abstract: A relative potency assay was based upon inhibition of a mAb binding to a cell-surface expressed antigen on viable cells and assessed via flow cytometry. The assay produced data that were variable and insufficiently accurate. To address the assay’s shortcomings, a new relative potency assay with similar molecular underpinnings was developed, based upon an AlphaLISA platform. The resulting assay was not only significantly more accurate and less variable than the original FACS assay, it was also overwhelmingly easier and faster to execute.

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