Catalent & Evonik’s Hot Melt Extrusion Workshop
Date: Thursday, March 12, 2020
Time: 8:30am- 3:00pm
Location: 14 Schoolhouse Road, Somerset, NJ 08873
Catalent and Evonik Industries are excited to announce a joint workshop titled, “A Deep Dive into the Technologies for Advanced Formulation and Targeted Delivery.”
Topics will include:
- Hot melt extrusion solid dispersion formulations and process development
- Hot melt extrusion for bioavailability enhancement and scale-up
- Formulation and scale-up strategies for controlled-release oral solid dosage forms
Followed by a lab demonstration and tour of Catalent’s Somerset facility.
Catalent & Evonik
Dr. Firouz Asgarzadeh
Formulation & Application Services
- Matching in vivo needs
- Overview of CR approaches
- Tablet film coating
- Multi-particulate coating using fluid bed
Ronald Vladyka, R.Ph
Formulation Research & Product Development
1:15 pm – 2:00 pm
St. John’s University
2:00 pm – 2:45 pm
- Amorphous solid dispersions to overcome poorly solubility
- CR formulations using HME
- Using polymer screening data to set critical process parameters
- HME scale-up
Sampada Upadhye, PhD
Firouz Asgarzadeh, Ph.D., is Director of Technical Marketing at Evonik Industries, supporting the Eudragit® modified-delivery product line. Dr. Asgarzadeh has over 20 years’ experience in the development of solid, liquid and injectable pharmaceutical formulations. His current focus at Evonik is the development of innovative formulations and processes for targeted oral drug delivery, injectable extended-release, and solubility and bioavailability enhancement of poorly soluble actives. Dr. Asgarzadeh earned his doctorate in Polymeric Materials and Composites from Université Claude Bernard (Lyon), France. He holds a master’s in physical chemistry of molecular and macromolecular materials from the Université Louis Pasteur (Strasbourg), France and in polymer engineering from the Polytechnic University, Tehran, Iran.
Ronald Vladyka, R.Ph., is Director of Product Development, Formulation Analytical Research & Development at Catalent. Mr. Vladyka has over 30 years of industry experience in various Product and drug delivery development roles. His areas of interest include the development of enabling drug delivery technologies and the design and development of formulations for modified-release dosage forms. He holds over 12 U.S. patents and has authored and contributed to numerous research articles. Mr. Vladyka received his bachelor’s degree in biology from Lebanon Valley College and a bachelor’s in Pharmacy from Arnold and Marie Schwartz College of Pharmacy, Long Island University.
Ketan Patel, Ph.D., is an Assistant Professor, Industrial Pharmacy at St. John’s University where his research laboratory focuses on the development of melanoma and pancreatic cancer-targeted nanoparticles, self-emulsifying systems, hot melt extrusion, abuse deterrent formulations, and vaginal films for HIV prevention. He has published over 40 research papers and three U.S. patents in the areas of cancer nanomedicine, oral and vaginal nano-formulations, 3D printing and abuse deterrent formulations. Dr. Patel received his doctorate in pharmaceutics from UDCT in Mumbai, India and completed his post-doctoral fellowship at Florida A&M University.
Sampada Upadhye, Ph.D., is Global Study Director, Hot Melt Extrusion Technology at Catalent. She is responsible for strategic and scientific execution of all HME bioavailability enhancement projects, ranging from early-phase development to commercial supply. Dr. Upadhye has extensive experience in solubilization or pre-clinical new chemical entities, and formulation design of amorphous solid dispersion technologies for hot melt extrusion and spray drying. She has several patents and peer-reviewed publications, including contributing chapters to: Melt Extrusion: Materials, Technology and Drug Product Design (edited by MA Repka, et. al.) and Contemporary Research Topics in Pharmaceutical Excipients (edited by Ajit Narang, et. al.). Dr. Upadhye received her doctorate from The University of Mississippi.