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Intranasal Drug Delivery: Identifying Challenges & New Product Opportunities
Date: Thursday, February 24, 2022
Time: 11:00am EST
The market continues to evolve with a variety of drug delivery solutions being sought beyond conventional oral dosage forms. The intranasal delivery route is frequently used for the local treatment of allergic rhinitis, nasal congestion, and cold symptoms. However, it has emerged as an alternative route of systemic delivery for a variety of indications such as migraine, seizures, breakthrough pain, and opioid overdose amongst others.

In this webinar, experts will discuss the challenges, opportunities, and advantages of intranasal drug delivery. An overview of the anatomy and physiology of the nasal cavity provides an appreciation of the rationale for intranasal drug delivery as well as key product development considerations. Experts will discuss the utility of PBPK modelling, along with API physicochemical properties, to predict the extent of systemic absorption after intranasal administration. The complex interplay between product attributes, drug exposure, and manufacturing processes will be further discussed.

Key learning objectives:

  • Overview of challenges and opportunities of intranasal drug delivery and why it has drawn increasing interest as a route of administration
  • Understand how PBPK modeling tools can predict drug absorption after intranasal administration and help formulation development
  • Intranasal drug product formulation design and optimization considerations to ensure in vivo performance and manufacturability

FEATURED SPEAKERS

​​Regina Scherließ
Department of Pharmaceutics and Biopharmaceutics
Kiel University

 

 

 

Jan Neelissen, PhD
Associate Director, DMPK Advisory Services
Catalent

 

 

David Wilcox
Director, Inhalation Product Development
Catalent

 

 


Kiran Amancha, PhD
Group Leader, Inhalation Product Development
Catalent