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  4.  » Twin-Screw Granulation as a Viable Pharmaceutical Process in the Shifting Manufacturing Paradigm

Twin-Screw Granulation as a Viable Pharmaceutical Process in the Shifting Manufacturing Paradigm

Date: March 23, 2023
Time: 11:00 am EDT

Event Overview

Particle size enlargement, through the addition of a liquid to a powder with agitation to produce agglomeration, is the conventional granulation method used in the pharmaceutical industry. However, this method introduces several processing steps that can increase the time, labor, and energy used. The twin-screw granulation process has emerged as an alternative robust and reproducible technique for continuous manufacturing of wet, melt and dry granulation. However, defining the process variables for twin-screw granulation can be tricky with significant effect on granules’ quality.

During this webinar, experts will present the principles, mechanisms and several downstream applications of patented twin-screw granulation technique for oral solid dosage forms. Join this webinar to know how the Quality by Design (QbD) approach can be applied to a continuous drug granulation process.

Key Learning Objectives:

  • Learn the principles and benefits of patented twin-screw granulation technique
  • Discuss key considerations for twin-screw granulation, equipment set up, QbD approaches and process analytical technology
  • Understand the potential of twin-screw granulation for development and manufacturing of pharmaceutical products


Michael A. Repka, Ph.D.
Director of the Pii Center for Pharmaceutical Technology, Distinguished Professor of Pharmaceutics and Drug Delivery
University of Mississippi



Hemlata Patil, Ph.D.
Manager, Hot Melt Extrusion Technology



Valérie Vanhoorne, Ph.D.
Professor of Pharmaceutical Technology
Ghent University, Belgium