Evaluation Of Digestion Approaches

Evaluation of Digestion Approaches for Determination of Elemental Impurities in Support of USP <232> and <233>

Authors: M.Cree, K.Davis,and S.Jones

USP is revising General Chapter <231> Heavy Metals to update methodology and establish acceptable limits for metal impurities. As sample matrix can significantly influence digestion performance and analytical accuracy, the purpose of this work is to develop suitable microwave digestion procedures to support USP General Chapters <232> and <233>.