Gelatin-free Softgels Compatability

Gelatin-free Softgels: Compatibility Studies of SEDDS and SMEDDS Capsule Fill Formulations

Authors: Norman Stroud, Keith Tanner, Elizabeth Youngblood, Didier Kiyali, Shawn McKee, Julien Meissonnier, Mathieu Schmitt, and Nathalie Sicre

Summary: A growing proportion of new drug candidates possess poor aqueous solubility. These molecules often suffer from low bioavailability, lack of dose proportionality, and high subject variability. In recent years formulation strategies have been developed to overcome these challenges that make use of self-emulsifying drug delivery systems (SEDDS) or self-microemulsifying drug delivery systems (SMEDDS). It has been demonstrated that novel, gelatin-free, polysaccharide-based softgel shells are compatible with ingredients and formulations used in SEDDS and SMEDDS. In certain cases, the polysaccharide capsule shell exhibits superior compatibility with SEDDS or SMEDDS, compared to conventional gelatin-based shells.