Kollicoat Protect Top-Coat

Effect of Kollicoat Protect Top-Coat on Long-Term Physical Stability of Enteric-Coated Softgels

Authors: I. McGuffy, K.Zhuang, S. Tindal, N. Langley

Enteric-coated softgels tend to agglomerate when stored at high temperature/RH conditions. This study evaluated the effect of a Kollicoat Protect Top-coat on the physical stability of enteric-coated softgels stored at 40-degrees C/75% RH (open dish and sealed HOPE bottles). Stability was measured by changes in agglomeration, softgel appearance, hardness, brittleness, and/or acid resistance in a disintegration text.