Twin-Screw Granulation as a Viable Pharmaceutical Process in the Shifting Manufacturing Paradigm
Summary: Particle size enlargement, through the addition of a liquid to a powder with agitation to produce agglomeration, is the conventional granulation method used in the pharmaceutical industry. However, this method introduces several processing steps that can increase the time, labor, and energy used. The twin-screw granulation process has emerged as an alternative robust and reproducible technique for continuous manufacturing of wet, melt and dry granulation. However, defining the process variables for twin-screw granulation can be tricky with significant effect on granules’ quality.
During this webinar, experts present the principles, mechanisms and several downstream applications of patented twin-screw granulation technique for oral solid dosage forms. Watch this webinar to know how the Quality by Design (QbD) approach can be applied to a continuous drug granulation process.