Model to Predict Process Parameters for Scale-Up of Hot Melt Extrusion Process
Summary: Technology transfer and scale-up from a laboratory-scale to commercial-scale HME process require several in-depth empirical studies during product development. Without prior calculations and in-silico scale-up models, this can consume large amounts of drug substance.
Download the technical note to learn about a mathematical approach to scale-up of hot melt extrusion (HME) from laboratory-scale to production-scale, applying the quality by design principle. By using this approach, technology transfer is successful in meeting the quality target product profile while consuming a minimal amount of the drug substance.