Advantages of Pharmaceutical Micronization: Catalent’s Global Expertise
Abstract: Pharmaceutical micronization, the process of reducing active pharmaceutical ingredient (API) particles to micrometer scale through advanced particle engineering technology, is essential for improving drug bioavailability and performance across diverse therapeutic applications. This particle size reduction technique plays a critical role in addressing one of the pharmaceutical industry’s most pressing challenges: poorly water-soluble compounds that represent a significant portion of today’s drug development pipeline. While some pharmaceutical companies may invest in costly in-house milling equipment or struggle with technology transfer between development and commercial manufacturing, leading innovators are partnering with CDMOs that offer integrated micronization services from clinical through commercial scale. This comprehensive white paper explores the fundamentals of pharmaceutical micronization technology, containment strategies for potent compounds, and how strategic CDMO partnerships enable faster, safer paths from concept to commercialization.