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  6.  » Optimization of Type I & II Lipid Based Drug Delivery System

Optimization of Type I and II Lipid Based Drug Delivery System to Limit Inter-variability Linked to the Food Effect, an In-vitro Study

Summary: To be well absorbed from the gastrointestinal (GI) tract, drug compounds has to be placed in several biopharmaceutical conditions to provide good oral exposure. Insure the stability and the solubility of the API in the GI fluids are the first parameters to control. An adequate formulation can impact these parameters. For poorly soluble drugs, lipid based formulations are established for their bioavailability improvement through the GI tract. These systems have been classified by C.W. Pouton in four classes depending on their composition. Those systems exhibit different behavior upon digestion and dispersion. Type I and II are known to be more dependent of the food effect. The purpose of this study is to examine how it could be possible to limit the individual variability of the type I and II systems with an adequate choice of the composition.

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