Zydis® Fast Dissolve Delivery Technology

Faster, more reliable delivery with the no. 1 orally disintegrating tablet

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Zydis®, our proprietary fast-dissolve technology, is a unique, freeze-dried oral solid dosage form that disperses instantly in the mouth - no water required. With more than 20 products launched in 50 countries, Zydis® fast dissolve continues to be the world’s best-in-class, orally disintegrating tablet (ODT) technology. Whether you are considering an ODT to enhance pharmacokinetics through pre-gastric absorption, looking for a way to improve patient compliance, or seeking a marketing advantage for a valued brand, Zydis® technology can help enhance the value of your investment and accelerate your product’s potential.

Catalent Benefits
  • Better pre-gastric absorption for certain drug compounds
    • Disperses instantly in the mouth, allowing for buccal absorption
  • Improved compliance for various therapeutic markets
    • Excellent for children, the elderly, pets, and those having trouble swallowing
  • More efficient delivery
    • Allows for faster onset of action and reduction of metabolites
  • Ideal for certain indications
    • Excellent for treating pain and other conditions where rapid dosing and absorption are required, including allergies and travel-related illness
  • Improved patient compliance
    • Faster absorption lends the possibility of reduced and less frequent dosage
  • Enhanced marketing appeal 
    • Fast-dissolve perceived by consumers as easier to swallow and faster-acting
  • Protection from counterfeiting
    • Tamper evident
Valuable Product Differentiation
  • High level of customer preference
  • Multiple colors and shapes
  • Embossing with corporate logos and product codes
  • Unique packaging, including child-resistant options
  • Taste masking and flavors formulated for specific markets, including pediatrics and veterinary medicine

Feature

Zydis Fast-Dissolve Technology

Loosely Compressed

Dispersion speed

-3 seconds

15-60 seconds

Mouth feel

Smooth

Gritty

Dose size

< 400 mg-Insoluable

< 500 mg

Taste masking

Yes

Yes

How It Is Made

Utilizing a unique lyophilization (freeze-drying) process to manufacture finished dosage units, Zydis® units are produced via a four-stage process:

  • Stage 1 - Mixing 
    • The bulk API is formulated into a liquid solution or suspension.
  • Stage 2 - Filling and freezing
    • The liquid is precisely filled into pre-formed blisters and passed through a specially designed cryogenic freezing process to control the ultimate size of the ice crystals. 
  • Stage 3 - Lyophilization
    • The frozen units are then transferred to large-scale freeze dryers for the lyophilization process. 
  • Stage 4 - Sealing
    • The blisters containing the dried Zydis® units are then sealed via a heat-seal process to protect the product from varying environmental conditions and ensure long-term stability.
How it works
Catalent Capabilities
  • Development teams in the U.S. and Europe
  • Bench, pilot, and full-scale cGMP manufacturing in the US and Europe
  • Fully validated and globally approved regulatory manufacturing sites with exemplary records
  • Expert management of potent and controlled drugs
  • Operational excellence and efficiency via Lean Six Sigma principles 
  • Full in-house analytical and regulatory services for product development and launch
Facilities

We have two fast dissolve dosage form facilities plants dedicated to Zydis® fast dissolve production.

  • Somerset, New Jersey, U.S.A.
    • Research and development
    • Pilot line
    • Commercial line with controlled and potent drug capabilities
    • FDA audited
  • Swindon, U.K.
    • Research and development
    • Pilot line with controlled and potent drug capabilities 
    • FDA and MCA audited
    • Controlled drug capabilities