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Plant Based Softgel Technology


As the inventor of softgel rotary die process, Catalent continues to lead the softgel industry with cutting-edge drug delivery innovations. Our award-winning soft capsule technology platform, OptiShell® Technology, further advances RP Scherer Softgel technology by providing development solutions for challenging drug compounds contained within complex fill formulations.

OptiShell capsules utilize a patented shell derived from plant polysaccharides that are ideally suited for the encapsulation of higher melting point fill formulations. Soft capsules containing semi-solid matrices for modified release of poorly soluble and/or poorly permeable drug compounds are now an option, only at Catalent! For immediate release applications, OptiShell technology expands the range of compatible excipients available for developing lipid-based capsule formulations, providing more solutions for solving unique drug delivery challenges.

OptiShell technology and Catalent RP Scherer Softgels combined enable encapsulation of broadened range of lipid-based formulations.

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  • Improves bioavailability for a greater number of poorly water-soluble and poorly permeable compounds
  • Modified or extended release of compounds from softgels
  • Solves complex development and formulation challenges beyond conventional softgel technology
  • Patented shell composition can handle:
    • Encapsulation of  high temperature fill formulations (up to 70˚C) for semi-solid and highly viscous fill formulations
    • Higher pH fill formulations
    • A wider range of compatible fill excipients for enhancing drug bioavailability and stability

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  • Proprietary technology and process with strong IP protection
  • Better patient adherence – easy to swallow
  • Gelatin-free products for expanded markets
  • Elimination of  shell odor and a non-distinguishing taste

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We have a long track record of customizing successful programs involving our proprietary advanced technologies:

  • Pre-formulation and feasibility studies
  • Solubility screening of New Chemical Entities
  • Softgel capsule fill formulation development
  • Small-scale lab encapsulation for early stability data and final formulation selection
  • Shell development
  • Strong IP (intellectual property) positions including fill formulations for improved bioavailability
  • Extensive technical support in softgel capsule product development
  • Reliable supply from clinical phases to commercial manufacturing
  • Contingency planning and quality assurance via our large global network

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Our deep formulation expertise supported by a global infrastructure of cGMP, FDA, EMA and locally accredited softgel facilities will provide a catalyst to your success by tailoring a unique drug delivery solution to bring your product faster to market.