From Candidate to Clinic: Strategies to Accelerate Your Molecule's Development Path
Summary: Development of orally administered small molecules is becoming more challenging as an increasing number of molecules in pipelines are exhibiting a trend toward higher lipophilicity and molecular weight, which can lead to poor solubility and bioavailability.
During this webcast, industry experts will introduce a fast and efficient development process that can help deliver the right clinical candidate, best formulation strategy, and an optimal dosage form to Phase 1. The presentation will also review details of some established data-driven approaches, including physiologically based pharmacokinetic (PBPK) modeling, parallel formulation screening, API sparing techniques, and optimal early dosing strategies that will help avoid development pitfalls and de-risk a molecule’s path to clinic.