LYOPHILIZATION – The Key to Creating Acceptable & Effective Fast-Dissolving Oral Formulations
Summary: A dosage form that is designed to dissolve in the mouth and be absorbed rapidly needs to meet a couple of key requirements. It must indeed disperse very quickly so that it does not hang around in the mouth and cause discomfort or fail to be absorbed effectively. Furthermore, if it is going to be acceptable to the patients, it must be palatable. A product that tastes unpleasant or has a disagreeable, gritty mouth feel is unlikely to gain widespread acceptance however effective it may otherwise be.
This article originally published in Drug Development and Delivery, March 2016 edition presents the key consideration in creating an effective fast dissolving oral formulation.