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NMR and Mass Spectrometry in Pharmaceutical Development

Summary: Nuclear Magnetic Resonance (NMR) spectroscopy and Mass Spectrometry (MS) are powerful techniques for the characterization and quantification of compounds.

Applications include:
-The ability to confirm the structure of compounds
-Determine purity and identify (and possibly quantify) process-related impurities, degradants, or other unknowns observed during liquid chromatography screening.

Together, NMR and MS analysis can definitively identify:
-Reference standards
-Active pharmaceutical ingredients (APIs)
-Final drug product composition.​

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