NMR and Mass Spectrometry in Pharmaceutical Development
Summary: Nuclear Magnetic Resonance (NMR) spectroscopy and Mass Spectrometry (MS) are powerful techniques for the characterization and quantification of compounds.
-The ability to confirm the structure of compounds
-Determine purity and identify (and possibly quantify) process-related impurities, degradants, or other unknowns observed during liquid chromatography screening.
Together, NMR and MS analysis can definitively identify:
-Active pharmaceutical ingredients (APIs)
-Final drug product composition.